Lack ofPRKD2andPRKD3kinase domain somatic mutations inPRKD1wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland
نویسندگان
چکیده
منابع مشابه
Polymorphous low-grade adenocarcinoma of the parotid gland.
Polymorphous low-grade adenocarcinoma (PLGA) of the parotid gland is rare. We describe a new case in which the patient underwent parotidectomy only to experience an extensive recurrence 2 years later. The recurrence was treated with radical surgical excision and radiation therapy, and the patient remained disease-free at 5 years of follow-up. We also review the literature on primary parotid PLGA.
متن کاملCribriform adenocarcinoma of minor salivary gland: A mimic of polymorphous low-grade adenocarcinoma
Adenocarcinoma is relatively less common on the tongue.[1] Polymorphous low‐grade adenocarcinoma (PLGA) is a malignant tumor of minor salivary glands which is slow growing and carries a low metastatic potential. Histologically, PLGA exhibits a spectrum of growth patterns such as cribriform, tubular, trabecular, fascicular and solid structures. Concentric whorls forming target‐like patterns are ...
متن کاملAn insight into diagnostically challenging salivary gland malignancy with case report: Polymorphous low grade adenocarcinoma
Polymorphous low‐grade adenocarcinoma (PLGA) is difficult to diagnose due to its indolent clinical presentation and due to its morphological diversity that includes several microscopic patterns. Distinguishing it from high‐grade tumors of salivary gland is important, as the management and prognosis of this tumor differ. We report a considerably rare case of PLGA in retromolar area highlighting ...
متن کاملSomatic mutations of the HER2 kinase domain in lung adenocarcinomas.
Mutations in the epidermal growth factor receptor gene (EGFR) in lung cancers predict for sensitivity to EGFR kinase inhibitors. HER2 (also known as NEU, EGFR2, or ERBB2) is a member of the EGFR family of receptor tyrosine kinases and plays important roles in the pathogenesis of certain human cancers, and mutations have recently been reported in lung cancers. We sequenced the tyrosine kinase do...
متن کاملPolymorphous low-grade adenocarcinoma.
Polymorphous low-grade adenocarcinomas are minor salivary gland neoplasms with a predilection for intraoral sites. Women are affected twice as frequently as men, and generally present in the fifth to sixth decade of life with a painless ihaoral mass. The palatal mass is, on average, about 2 cm in greatest dimension. The tumors are submucosal, identified below an intact mucosa as a well-circumsc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Histopathology
سال: 2016
ISSN: 0309-0167
DOI: 10.1111/his.12883